PLP1

Across TCGA patient cohorts, PLP1 protein abundance is significantly associated with the protein abundance of many other proteins, with 18,217 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLP1-associated proteins across cancer lineages are TPPP, CCDC137_S19, and FLNA_S977. Each is linked with PLP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLP1-to-partner and partner-to-PLP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLP1 versus TPPP in GBM, with a Pearson correlation of 0.82.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLP1→partner) and Y-score (partner→PLP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TPPP →	+1.115	+1.605	<.001	<.001	3	4
HNSC	CCDC137_S19 →	-0.635	-0.825	<.001	<.001	2	4
COAD	FLNA_S977 →	+1.131	+0.875	<.001	<.001	3	3
GBM	CA4 →	+0.606	+1.043	<.001	<.001	3	3
GBM	CD81 →	+0.546	+1.386	<.001	<.001	3	3
GBM	RPF2 →	-0.385	-1.306	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,217 associations by consensus.

PLP1 vs TPPP — GBM

Explore this scatter interactively →