PLP1

Across TCGA patient cohorts, PLP1 mutation is significantly associated with the RNA expression of many other genes, with 3,754 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLP1-associated genes across cancer lineages are RNU6-939P, RNU6-537P, and RN7SL478P. Each is linked with PLP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLP1-to-partner and partner-to-PLP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-939P grouped by PLP1-low versus PLP1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLP1→partner) and Y-score (partner→PLP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNU6-939P →	+0.301	+7.914	<.001	<.001	3	3
LUAD	RNU6-537P →	+0.327	+3.480	<.001	.005	3	3
UCEC	RN7SL478P →	+0.185	+1.726	<.001	.002	3	2
HNSC	FSBP →	+0.021	+3.952	<.001	.005	3	2
COAD	RNA5SP394 →	+0.469	+3.942	<.001	.002	3	2
COAD	TRAJ42 →	+0.974	+3.245	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,754 associations by consensus.

RNU6-939P by PLP1 expression — LIHC

Explore this box plot interactively →