PLP1

Across TCGA cell cohorts, PLP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,963 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLP1-associated GO terms across cancer lineages are Regulation of TORC1 signaling, Endosomal transport, and Protein polyubiquitination. Each is linked with PLP1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PLP1-to-partner and partner-to-PLP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of TORC1 signaling grouped by PLP1-low versus PLP1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLP1→partner) and Y-score (partner→PLP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of TORC1 signaling →	+0.051	+0.707	<.001	.003	3	8
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.066	+0.321	<.001	.009	3	6
BLOOD_Leukemia	Protein polyubiquitination →	+0.034	+0.174	<.001	<.001	3	6
BLOOD_Leukemia	Mitotic cytokinesis →	+0.060	+0.129	<.001	.001	3	6
CNS	Urate transport →	-0.521	-1.305	.006	.004	3	6
BLOOD_Leukemia	Cytoskeleton-dependent cytokinesis →	+0.051	+0.150	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,963 associations by consensus.

Regulation of TORC1 signaling by PLP1 expression — LUNG_SCLC

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