PLP1

Across TCGA cell cohorts, PLP1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PLP1-associated genes across cancer lineages are OR2L5, KRTAP7-1, and APOBEC1. Each is linked with PLP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLP1-to-partner and partner-to-PLP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L5 grouped by PLP1-low versus PLP1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLP1→partner) and Y-score (partner→PLP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2L5 →	+0.022	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	KRTAP7-1 →	+0.140	+4.887	<.001	.009	3	1
CNS	APOBEC1 →	+0.017	+4.754	<.001	.005	3	1
CNS	ZNF831 →	+0.088	+4.832	<.001	.002	3	1
CNS	IL22RA2 →	+0.529	+4.169	<.001	.008	3	1
CNS	PLA2G2C →	+0.004	+4.754	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR2L5 by PLP1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →