PLOD2

Across TCGA patient cohorts, PLOD2 protein abundance is significantly associated with the RNA expression of many other genes, with 19,407 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLOD2-associated genes across cancer lineages are PFKFB4, LOXL2, and LNCSRLR. Each is linked with PLOD2 in more than 9 cancer types. Because this analysis shows association rather than direction, both PLOD2-to-partner and partner-to-PLOD2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLOD2 versus PFKFB4 in UCEC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLOD2→partner) and Y-score (partner→PLOD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PFKFB4 →	+0.848	+0.543	<.001	<.001	3	10
PDAC	LOXL2 →	+1.363	+1.004	<.001	<.001	3	10
HNSC	LNCSRLR →	+1.168	+0.810	<.001	<.001	3	10
GBM	LGALS1 →	+0.907	+0.898	<.001	<.001	3	9
CCRCC	LOX →	+1.681	+1.225	<.001	<.001	3	9
OV	FN1 →	+3.229	+1.187	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,407 associations by consensus.

PLOD2 vs PFKFB4 — UCEC

Explore this scatter interactively →