PLOD2

Across TCGA cell cohorts, PLOD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,696 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PLOD2-associated GO terms across cancer lineages are Response to hypoxia, Response to decreased oxygen levels, and Collagen fibril organization. Each is linked with PLOD2 in more than 13 cancer types. Because this analysis shows association rather than direction, both PLOD2-to-partner and partner-to-PLOD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to hypoxia grouped by PLOD2-low versus PLOD2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLOD2→partner) and Y-score (partner→PLOD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Response to hypoxia →	+0.065	+1.995	.007	.004	3	14
LIVER	Response to decreased oxygen levels →	+0.072	+2.349	.001	.009	3	14
LUNG_NSCLC_LUSC	Collagen fibril organization →	+0.347	+3.657	.001	<.001	3	14
PANCREAS	Oncostatin-M-mediated signaling pathway →	+0.200	+2.230	<.001	<.001	3	13
LIVER	Response to oxygen levels →	+0.064	+2.339	<.001	.007	3	13
LUNG_NSCLC_LUSC	Peptidyl-lysine oxidation →	+1.541	+2.914	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,696 associations by consensus.

Response to hypoxia by PLOD2 expression — LIVER

Explore this box plot interactively →