PLOD2

Across TCGA cell cohorts, PLOD2 mutation is significantly associated with the RNA expression of many other genes, with 738 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLOD2-associated genes across cancer lineages are EIF3L, CBY1, and POLDIP3. Each is linked with PLOD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLOD2-to-partner and partner-to-PLOD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF3L grouped by PLOD2-low versus PLOD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLOD2→partner) and Y-score (partner→PLOD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EIF3L →	+0.490	+3.087	.006	.006	3	1
LARGE_INTESTINE	CBY1 →	+0.689	+3.451	<.001	.002	3	1
LARGE_INTESTINE	POLDIP3 →	+0.730	+3.169	<.001	.006	3	1
LARGE_INTESTINE	TAB1 →	+0.772	+3.364	<.001	.002	3	1
LARGE_INTESTINE	MTMR3 →	+0.742	+3.364	.001	.002	3	1
LARGE_INTESTINE	TNRC6B →	+0.998	+3.234	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 738 associations by consensus.

EIF3L by PLOD2 expression — LARGE_INTESTINE

Explore this box plot interactively →