PLOD1

Across TCGA patient cohorts, PLOD1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLOD1-associated genes across cancer lineages are GATA3, p62 Lck ligand, and STAT3_pY705. Each is linked with PLOD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLOD1-to-partner and partner-to-PLOD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA3 grouped by PLOD1-low versus PLOD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLOD1→partner) and Y-score (partner→PLOD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA3 →	+0.210	+3.321	.013	.009	3	2
UCEC	p62 Lck ligand →	+0.600	+3.331	<.001	.005	3	2
UCEC	STAT3_pY705 →	-0.417	-2.000	<.001	.032	3	2
UCEC	ATM →	-0.846	-3.807	<.001	<.001	3	2
UCEC	ERK2 →	+0.281	+2.700	.001	.006	3	1
UCEC	ETS-1 →	+0.375	+3.807	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

GATA3 by PLOD1 expression — UCEC

Explore this box plot interactively →