PLOD1

Across TCGA cell cohorts, PLOD1 mutation is significantly associated with the drug of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLOD1-associated genes across cancer lineages are KU-60019, GSK2606414, and KRAS (G12C) Inhibitor-12. Each is linked with PLOD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLOD1-to-partner and partner-to-PLOD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KU-60019 grouped by PLOD1-low versus PLOD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLOD1→partner) and Y-score (partner→PLOD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KU-60019 →	+0.518	+2.710	.008	.027	3	1
LARGE_INTESTINE	GSK2606414 →	+0.338	+2.184	.046	.030	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.507	+2.894	.019	.016	3	1
LARGE_INTESTINE	CPI-637 →	+0.511	+2.807	.011	.044	3	1
LARGE_INTESTINE	GSK690693 →	+0.474	+2.067	.032	.033	3	1
LARGE_INTESTINE	Brivanib →	+0.306	+2.067	.045	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

KU-60019 by PLOD1 expression — LARGE_INTESTINE

Explore this box plot interactively →