Across TCGA patient cohorts, PLN mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLN-associated genes across cancer lineages are EGFR_pY1068, Ku80, and Rab11. Each is linked with PLN in more than 1 cancer types. Because this analysis shows association rather than direction, both PLN-to-partner and partner-to-PLN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLN→partner) and Y-score (partner→PLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.334	-2.584	.004	.011	3	1
UCEC	Ku80 →	+0.357	+3.013	.001	.018	3	1
UCEC	Rab11 →	-0.160	-3.169	.018	.018	3	1
UCEC	Annexin-1 →	+0.980	+3.700	<.001	.001	3	1
UCEC	Shc_pY317 →	-0.214	-2.584	.002	.011	3	1
UCEC	TIGAR →	+0.141	+1.901	.048	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

PLN survival (RNA) · tumor vs normal (RNA) · all PLN data types