PLLPP1

Across TCGA pan-cancer cohorts, PLLPP1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of PLLPP1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where PLLPP1 RNA is repressed in tumor relative to normal tissue. In most cancer types PLLPP1 is over-expressed in tumor, although a few such as LUSC and ESCA show the opposite, repressed pattern.

LUSC and ESCA are the cancer types where PLLPP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLLPP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	−0.039	.010	2	view →
ESCA	Female	All	−0.130	.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

PLLPP1–LUSC

Open the LUSC breakdown →