Across TCGA patient cohorts, PLK5 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,530 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLK5-associated proteins across cancer lineages are UGGT1, REEP6, and LARS2. Each is linked with PLK5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLK5-to-partner and partner-to-PLK5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLK5→partner) and Y-score (partner→PLK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	UGGT1 →	-0.185	-0.408	.004	.009	3	3
BRCA	REEP6 →	+0.897	+0.194	<.001	.004	3	3
GBM	LARS2 →	+0.302	+0.315	.003	.003	3	3
LSCC	TBC1D2B_S155 →	-0.378	-0.265	.004	.003	3	3
GBM	MXRA5_S1525 →	-1.289	-0.363	<.001	<.001	3	3
GBM	MYH9_S1943 →	-0.612	-0.433	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,530 associations by consensus.

Exploration

PLK5 survival (RNA) · tumor vs normal (RNA) · all PLK5 data types