Across TCGA cell cohorts, PLK5 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLK5-associated genes across cancer lineages are CDH20, OR5C1, and DDX4. Each is linked with PLK5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLK5-to-partner and partner-to-PLK5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLK5→partner) and Y-score (partner→PLK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDH20 →	+0.163	+4.392	<.001	.004	3	1
LARGE_INTESTINE	OR5C1 →	+0.057	+3.793	<.001	.007	3	1
LARGE_INTESTINE	DDX4 →	+0.037	+4.032	.001	.004	3	1
LARGE_INTESTINE	BPIFB6 →	+0.020	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR1L6 →	+0.022	+4.437	<.001	.004	3	1
LARGE_INTESTINE	ADH1A →	+0.160	+3.920	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

PLK5 survival (RNA) · tumor vs normal (RNA) · all PLK5 data types