PLK4

Across TCGA patient cohorts, PLK4 RNA expression is significantly associated with the protein abundance of many other proteins, with 23,448 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLK4-associated proteins across cancer lineages are RFC1_T506, RPL12_S38, and RRM1. Each is linked with PLK4 in more than 9 cancer types. Because this analysis shows association rather than direction, both PLK4-to-partner and partner-to-PLK4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLK4 versus RFC1_T506 in LUAD, with a Pearson correlation of 0.73.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLK4→partner) and Y-score (partner→PLK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RFC1_T506 →	+1.262	+1.172	<.001	<.001	3	10
LUAD	RPL12_S38 →	+1.270	+1.053	<.001	<.001	3	10
COAD	RRM1 →	+0.581	+0.799	<.001	<.001	3	10
LUAD	RRM2 →	+0.974	+1.153	<.001	<.001	3	10
LUAD	KPNA2 →	+0.727	+1.077	<.001	<.001	3	10
UCEC	MAD2L1 →	+0.553	+1.007	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,448 associations by consensus.

PLK4 vs RFC1_T506 — LUAD

Explore this scatter interactively →