PLK4

Across TCGA patient cohorts, PLK4 mutation is significantly associated with the RNA expression of many other genes, with 3,652 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLK4-associated genes across cancer lineages are TUBB8P5, RNA5SP417, and OR7E18P. Each is linked with PLK4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLK4-to-partner and partner-to-PLK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBB8P5 grouped by PLK4-low versus PLK4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLK4→partner) and Y-score (partner→PLK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TUBB8P5 →	+0.036	+5.208	.002	.001	3	3
UCEC	RNA5SP417 →	+0.368	+1.936	<.001	.001	3	3
CESC	OR7E18P →	+0.028	+4.020	<.001	.009	3	2
CESC	KRTAP4-3 →	+0.069	+5.263	<.001	.001	3	2
CESC	ZNF299P →	+0.013	+4.516	<.001	.004	3	2
LUSC	RNA5SP413 →	+0.567	+4.496	.003	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,652 associations by consensus.

TUBB8P5 by PLK4 expression — SKCM

Explore this box plot interactively →