PLK4

Across TCGA patient cohorts, PLK4 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLK4-associated genes across cancer lineages are ATM, eEF2, and Myosin-IIa_pS1943. Each is linked with PLK4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLK4-to-partner and partner-to-PLK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PLK4-low versus PLK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLK4→partner) and Y-score (partner→PLK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.522	-2.807	<.001	.003	3	3
UCEC	eEF2 →	+0.355	+2.115	.004	.016	3	2
UCEC	Myosin-IIa_pS1943 →	+0.156	+1.453	.029	.015	3	2
UCEC	Notch1 →	+0.124	+1.710	.011	.025	3	2
UCEC	PDCD4 →	-0.471	-1.575	.003	.034	3	2
UCEC	Chk2_pT68 →	-0.138	-1.575	.032	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ATM by PLK4 expression — UCEC

Explore this box plot interactively →