PLK4

Across TCGA cell cohorts, PLK4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,891 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLK4-associated GO terms across cancer lineages are Microtubule cytoskeleton organization involved in mitosis, Positive regulation of chromosome organization, and Mitotic spindle elongation. Each is linked with PLK4 in more than 19 cancer types. Because this analysis shows association rather than direction, both PLK4-to-partner and partner-to-PLK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule cytoskeleton organization involved in mitosis grouped by PLK4-low versus PLK4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLK4→partner) and Y-score (partner→PLK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Microtubule cytoskeleton organization involved in mitosis →	+0.147	+1.653	<.001	<.001	3	20
BONE	Positive regulation of chromosome organization →	+0.110	+1.557	<.001	<.001	3	20
BONE	Mitotic spindle elongation →	+0.339	+1.606	<.001	<.001	3	20
OESOPHAGUS	Nuclear division →	+0.129	+1.335	<.001	<.001	3	20
BREAST	Positive regulation of cytokinesis →	+0.129	+1.148	.001	<.001	3	20
BONE	Regulation of chromosome organization →	+0.126	+1.660	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,891 associations by consensus.

Microtubule cytoskeleton organization involved in mitosis by PLK4 expression — BONE

Explore this box plot interactively →