PLK4

Across TCGA cell cohorts, PLK4 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLK4-associated genes across cancer lineages are NPAP1, MRAP, and LCE4A. Each is linked with PLK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLK4-to-partner and partner-to-PLK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPAP1 grouped by PLK4-low versus PLK4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLK4→partner) and Y-score (partner→PLK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NPAP1 →	+0.142	+5.662	<.001	.002	3	2
UPPER_AERODIGESTIVE_TRACT	MRAP →	+0.028	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	LCE4A →	+0.098	+4.736	.007	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.663	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.085	+5.539	<.001	.003	3	1
BLOOD_Leukemia	AADACL2 →	+0.012	+4.922	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

NPAP1 by PLK4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →