PLK2

Across TCGA patient cohorts, PLK2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLK2-associated genes across cancer lineages are ACC1, PDCD4, and ATM. Each is linked with PLK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLK2-to-partner and partner-to-PLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by PLK2-low versus PLK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLK2→partner) and Y-score (partner→PLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.268	+1.887	.028	.029	3	2
UCEC	PDCD4 →	-0.463	-1.896	.003	.015	3	2
UCEC	ATM →	-0.568	-2.401	<.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.634	+1.785	.001	.007	3	2
UCEC	4E-BP1 →	+0.297	+3.584	.001	.002	3	2
UCEC	14-3-3_beta →	-0.093	-2.088	.005	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ACC1 by PLK2 expression — UCEC

Explore this box plot interactively →