PLK2

Across TCGA cell cohorts, PLK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,583 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PLK2-associated GO terms across cancer lineages are Regulation of cell-substrate adhesion, Regulation of cell-matrix adhesion, and Viral process. Each is linked with PLK2 in more than 14 cancer types. Because this analysis shows association rather than direction, both PLK2-to-partner and partner-to-PLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate adhesion grouped by PLK2-low versus PLK2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLK2→partner) and Y-score (partner→PLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-substrate adhesion →	+0.130	+3.710	<.001	<.001	3	15
BONE	Regulation of cell-matrix adhesion →	+0.151	+3.849	<.001	<.001	3	15
BONE	Viral process →	+0.100	+3.243	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Wound healing →	+0.137	+3.079	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate adhesion →	+0.160	+3.617	<.001	<.001	3	13
STOMACH	Positive regulation of extrinsic apoptotic signaling pathway →	+0.136	+2.411	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,583 associations by consensus.

Regulation of cell-substrate adhesion by PLK2 expression — BONE

Explore this box plot interactively →