PLK2

Across TCGA cell cohorts, PLK2 mutation is significantly associated with the RNA expression of many other genes, with 1,291 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLK2-associated genes across cancer lineages are IFNA8, TGM7, and OR2T12. Each is linked with PLK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLK2-to-partner and partner-to-PLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA8 grouped by PLK2-low versus PLK2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLK2→partner) and Y-score (partner→PLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IFNA8 →	+0.034	+4.930	<.001	.008	3	1
SOFT_TISSUE	TGM7 →	+0.006	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR2T12 →	+0.586	+5.977	<.001	.001	3	1
SOFT_TISSUE	TAS2R60 →	+0.021	+4.930	.001	.008	3	1
SOFT_TISSUE	SCGB1C1 →	+0.073	+5.977	<.001	.001	3	1
SOFT_TISSUE	PRSS45P →	+0.206	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,291 associations by consensus.

IFNA8 by PLK2 expression — SOFT_TISSUE

Explore this box plot interactively →