PLK1

Across TCGA pan-cancer cohorts, PLK1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PLK1 data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PLK1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PLK1 expression acts as an unfavorable survival marker.

LUAD, COAD, and SKCM are the cancer types where PLK1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.206	0.685	.001	18	view →
COAD	DFS	Median	All	0.173	0.578	.002	7	view →
SKCM	DFS	Median	All	0.349	0.643	.013	7	view →
CESC	OS	Median	II,III,IV	0.203	0.759	.021	6	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PLK1–LUAD (OS)

Open the LUAD breakdown →