PLK1

Across TCGA pan-cancer cohorts, PLK1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PLK1 data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PLK1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PLK1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

PDAC, HNSC, and UCEC are the cancer types where PLK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.300	0.739	<.001	51	view →
HNSC	OS	Quartile	All	0.814	0.930	.011	11	view →
UCEC	DFS	Median	III,IV	0.891	0.280	.026	4	view →
LSCC	DFS	Median	All	0.908	0.599	.014	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PLK1–PDAC (DFS)

Open the PDAC breakdown →