PLK1

Across TCGA patient cohorts, PLK1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,126 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PLK1-associated genes across cancer lineages are NCAPG, RAD51AP1, and TTK. Each is linked with PLK1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PLK1-to-partner and partner-to-PLK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLK1 versus NCAPG in UCEC, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLK1→partner) and Y-score (partner→PLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPG →	+1.009	+0.528	<.001	<.001	3	7
BRCA	RAD51AP1 →	+1.271	+0.681	<.001	<.001	3	7
LUAD	TTK →	+1.091	+0.769	<.001	<.001	3	7
UCEC	KIF20A →	+1.339	+0.569	<.001	.002	3	7
BRCA	ANLN →	+1.376	+0.556	<.001	<.001	3	7
BRCA	CENPA →	+1.222	+0.548	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,126 associations by consensus.

PLK1 vs NCAPG — UCEC

Explore this scatter interactively →