PLK1

Across TCGA patient cohorts, PLK1 mutation is significantly associated with the RNA expression of many other genes, with 2,429 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLK1-associated genes across cancer lineages are EIF4E, BUB3, and TYW3. Each is linked with PLK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLK1-to-partner and partner-to-PLK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF4E grouped by PLK1-low versus PLK1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLK1→partner) and Y-score (partner→PLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EIF4E →	+0.488	+3.611	.006	.001	3	3
UCEC	BUB3 →	+0.479	+3.075	<.001	<.001	3	3
COAD	TYW3 →	+0.542	+3.625	.001	.001	3	3
UCEC	SLBP →	+0.510	+2.332	.002	<.001	3	3
UCEC	UTP15 →	+0.405	+2.397	.001	<.001	3	3
UCEC	SFXN1 →	+0.505	+2.807	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,429 associations by consensus.

EIF4E by PLK1 expression — COAD

Explore this box plot interactively →