Across TCGA pan-cancer cohorts, PLIN5 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PLIN5 data layer compared with 27 for mass-spec protein and 2 for mass-spec protein.
The strongest signal is observed in thyroid carcinoma (THCA), where higher PLIN5 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PLIN5 expression acts as an unfavorable survival marker.
THCA, SARC, and UCEC are the cancer types where PLIN5 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.