Across TCGA pan-cancer cohorts, PLIN5 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PLIN5 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PLIN5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PLIN5 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD and HNSC are the cancer types where PLIN5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	1.000	0.417	.023	4	view →
HNSC	OS	Tertile	IV	0.855	0.510	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: PLIN5 tumor-vs-normal RNA expression · all PLIN5 data types