Across TCGA patient cohorts, PLIN5 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PLIN5-associated genes across cancer lineages are eIF4E, GAPDH, and 4E-BP1_pS65. Each is linked with PLIN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLIN5-to-partner and partner-to-PLIN5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLIN5→partner) and Y-score (partner→PLIN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.191	+2.459	.024	.020	3	1
SKCM	GAPDH →	+0.557	+3.000	.047	.034	3	1
SKCM	4E-BP1_pS65 →	+0.215	+2.820	.023	.035	3	1
UCEC	HER3 →	-0.358	-3.156	.017	.020	2	1
UCEC	Caspase-7-cleavedD198 →	+1.229	+3.169	<.001	.020	1	2
UCEC	Chk2_pT68 →	-0.260	-3.169	.011	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

PLIN5 survival (RNA) · tumor vs normal (RNA) · all PLIN5 data types