PLIN4

Across TCGA pan-cancer cohorts, PLIN4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PLIN4 data layer compared with 23 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PLIN4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PLIN4 expression acts as an unfavorable survival marker.

KIRP, KICH, and PRAD are the cancer types where PLIN4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.165	0.709	<.001	21	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
PRAD	DFS	Median	All	0.113	0.935	<.001	6	view →
SKCM	DFS	Median	IV	0.040	0.454	.028	6	view →
LGG	OS	Median	All	0.591	0.911	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PLIN4–KIRP (OS)

Open the KIRP breakdown →