PLIN4

Across TCGA pan-cancer cohorts, PLIN4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PLIN4 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PLIN4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PLIN4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where PLIN4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	IV	0.781	0.220	.017	15	view →
PDAC	OS	Tertile	II,III,IV	0.630	0.305	.014	12	view →
HNSC	OS	Tertile	II,III,IV	0.925	1.000	.013	10	view →
GBM	OS	Tertile	All	0.275	0.500	.015	9	view →
COAD	DFS	Median	IV	0.565	1.000	.028	6	view →
LSCC	DFS	Tertile	All	1.000	0.471	.013	6	view →
LUAD	DFS	Quartile	II,III,IV	0.738	0.985	.032	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PLIN4–CCRCC (DFS)

Open the CCRCC breakdown →