PLIN3

Across TCGA pan-cancer cohorts, PLIN3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PLIN3 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PLIN3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PLIN3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where PLIN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.506	0.850	<.001	97	view →
LUAD	OS	Quartile	All	0.623	0.969	.004	13	view →
HNSC	OS	Median	All	1.000	0.484	.038	8	view →
LSCC	DFS	Quartile	II,III,IV	0.491	0.826	.019	7	view →
GBM	DFS	Quartile	All	0.259	0.408	.006	5	view →
UCEC	DFS	Quartile	II,III,IV	1.000	0.566	.033	4	view →
PDAC	DFS	Tertile	IV	0.182	0.515	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PLIN3–CCRCC (DFS)

Open the CCRCC breakdown →