PLIN3

Across TCGA cell cohorts, PLIN3 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLIN3-associated genes across cancer lineages are OR4N4, TPRX1, and GFRAL. Each is linked with PLIN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLIN3-to-partner and partner-to-PLIN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4N4 grouped by PLIN3-low versus PLIN3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLIN3→partner) and Y-score (partner→PLIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR4N4 →	+0.071	+3.643	.002	.007	3	2
OESOPHAGUS	TPRX1 →	+0.019	+4.392	<.001	.003	3	1
OESOPHAGUS	GFRAL →	+0.007	+4.857	<.001	<.001	3	1
OESOPHAGUS	OR2F1 →	+0.016	+4.392	<.001	.003	3	1
OESOPHAGUS	APOC4 →	+0.096	+4.017	<.001	.007	3	1
LUNG_NSCLC_LUAD	COX4I2 →	+0.095	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

OR4N4 by PLIN3 expression — CNS

Explore this box plot interactively →