PLIN2

Across TCGA patient cohorts, PLIN2 protein abundance is significantly associated with the RNA expression of many other genes, with 15,801 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLIN2-associated genes across cancer lineages are MMP8, SLC2A5, and RAB42. Each is linked with PLIN2 in more than 6 cancer types. Because this analysis shows association rather than direction, both PLIN2-to-partner and partner-to-PLIN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLIN2 versus MMP8 in GBM, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLIN2→partner) and Y-score (partner→PLIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MMP8 →	+0.667	+1.007	<.001	<.001	3	7
LUAD	SLC2A5 →	+0.990	+1.057	<.001	<.001	3	7
GBM	RAB42 →	+1.029	+1.269	<.001	<.001	3	7
BRCA	CEBPB →	+1.220	+1.085	<.001	<.001	3	6
OV	C5orf46 →	+1.177	+0.554	.005	.009	3	6
PDAC	SLAMF9 →	+1.318	+1.068	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,801 associations by consensus.

PLIN2 vs MMP8 — GBM

Explore this scatter interactively →