PLIN2

Across TCGA patient cohorts, PLIN2 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLIN2-associated genes across cancer lineages are p27_pT198, PTEN, and Rad50. Each is linked with PLIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLIN2-to-partner and partner-to-PLIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by PLIN2-low versus PLIN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLIN2→partner) and Y-score (partner→PLIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.174	+3.000	.005	.037	1	2
UCEC	PTEN →	-0.453	-3.000	.048	.037	1	1
UCEC	Rad50 →	-0.289	-3.000	.039	.037	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

p27_pT198 by PLIN2 expression — UCEC

Explore this box plot interactively →