PLIN1

Across TCGA patient cohorts, PLIN1 mutation is significantly associated with the RNA expression of many other genes, with 1,047 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLIN1-associated genes across cancer lineages are RNU6-1318P, FDX1P2, and SAPCD2P3. Each is linked with PLIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLIN1-to-partner and partner-to-PLIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1318P grouped by PLIN1-low versus PLIN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLIN1→partner) and Y-score (partner→PLIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1318P →	+0.449	+3.484	<.001	<.001	3	2
UCEC	FDX1P2 →	+0.137	+2.927	<.001	<.001	3	2
UCEC	SAPCD2P3 →	+0.105	+2.137	.007	.005	3	2
BRCA	WBP1LP8 →	+0.074	+9.057	<.001	.003	3	1
LUAD	EXTL2P1 →	+0.171	+5.343	<.001	.006	3	1
LUAD	COX6CP15 →	+0.371	+5.798	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,047 associations by consensus.

RNU6-1318P by PLIN1 expression — UCEC

Explore this box plot interactively →