PLIN1

Across TCGA patient cohorts, PLIN1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLIN1-associated genes across cancer lineages are JNK2, MEK1, and Notch1. Each is linked with PLIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLIN1-to-partner and partner-to-PLIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PLIN1-low versus PLIN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLIN1→partner) and Y-score (partner→PLIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.252	+2.817	.006	.036	3	1
UCEC	MEK1 →	+0.435	+3.321	.010	.010	3	1
UCEC	Notch1 →	+0.150	+3.009	.022	.019	3	1
UCEC	Shc_pY317 →	-0.197	-2.584	.005	.011	3	1
UCEC	VHL →	-0.975	-2.321	.002	.034	3	1
UCEC	XBP1 →	-0.196	-2.308	.002	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

JNK2 by PLIN1 expression — UCEC

Explore this box plot interactively →