PLIN1

Across TCGA cell cohorts, PLIN1 mutation is significantly associated with the drug of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLIN1-associated genes across cancer lineages are Vismodegib, Venetoclax, and SGC0946. Each is linked with PLIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLIN1-to-partner and partner-to-PLIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vismodegib grouped by PLIN1-low versus PLIN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLIN1→partner) and Y-score (partner→PLIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Vismodegib →	+0.390	+2.684	.007	.035	3	1
LARGE_INTESTINE	Venetoclax →	+0.440	+2.777	.005	.038	3	1
LARGE_INTESTINE	SGC0946 →	+0.298	+2.710	.036	.043	3	1
LARGE_INTESTINE	Cytarabine →	+0.898	+2.655	.020	.044	2	1
LARGE_INTESTINE	Oxaliplatin →	+0.541	+2.871	.031	.021	2	1
LARGE_INTESTINE	LY2109761 →	+0.372	+2.868	.018	.022	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Vismodegib by PLIN1 expression — LARGE_INTESTINE

Explore this box plot interactively →