PLGLA

Across TCGA patient cohorts, PLGLA mutation is significantly associated with the RNA expression of many other genes, with 548 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLGLA-associated genes across cancer lineages are AAGAB, MIR4701, and RNA5SP423. Each is linked with PLGLA in more than 1 cancer types. Because this analysis shows association rather than direction, both PLGLA-to-partner and partner-to-PLGLA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AAGAB grouped by PLGLA-low versus PLGLA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLGLA→partner) and Y-score (partner→PLGLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AAGAB →	+0.617	+3.364	.002	.005	3	2
SKCM	MIR4701 →	+0.736	+3.353	.005	.005	3	2
LUAD	RNA5SP423 →	+0.318	+7.930	<.001	.008	3	2
SKCM	SH2D6 →	+0.326	+3.464	<.001	.003	3	2
UCEC	EDC3 →	+0.401	+3.343	.008	.005	3	2
UCEC	COG8 →	+0.623	+3.386	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 548 associations by consensus.

AAGAB by PLGLA expression — UCEC

Explore this box plot interactively →