PLG

Across TCGA pan-cancer cohorts, PLG mass-spec protein is linked to patient survival in 9 of 34 cancer types, making it a survival-associated PLG data layer compared with 21 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PLG mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PLG expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

COAD, LUAD, and CCRCC are the cancer types where PLG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.879	1.000	.019	60	view →
LUAD	OS	Quartile	III,IV	0.372	0.950	.006	20	view →
CCRCC	DFS	Median	II,III,IV	0.235	0.887	.005	11	view →
UCEC	DFS	Tertile	III,IV	0.409	1.000	.010	10	view →
PDAC	OS	Median	II,III,IV	0.695	0.957	.007	9	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.909	.018	5	view →
LSCC	OS	Median	All	0.920	1.000	.009	5	view →
OV	DFS	Median	All	1.000	0.870	.037	4	view →
GBM	DFS	Median	All	0.429	0.219	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

PLG–COAD (DFS)

Open the COAD breakdown →