PLG

Across TCGA patient cohorts, PLG mutation is significantly associated with the RNA expression of many other genes, with 6,081 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLG-associated genes across cancer lineages are MTRF1L, PCCB, and LRRC42. Each is linked with PLG in more than 3 cancer types. Because this analysis shows association rather than direction, both PLG-to-partner and partner-to-PLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRF1L grouped by PLG-low versus PLG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLG→partner) and Y-score (partner→PLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTRF1L →	+0.307	+2.180	.001	.001	3	4
UCEC	PCCB →	+0.553	+2.214	<.001	<.001	3	4
UCEC	LRRC42 →	+0.592	+4.353	<.001	<.001	3	4
UCEC	DLGAP5 →	+0.861	+1.964	<.001	<.001	3	4
UCEC	PARP2 →	+0.558	+2.192	<.001	<.001	3	4
UCEC	RTN4IP1 →	+0.384	+1.790	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,081 associations by consensus.

MTRF1L by PLG expression — UCEC

Explore this box plot interactively →