PLG

Across TCGA patient cohorts, PLG mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PLG-associated genes across cancer lineages are TFRC, GAPDH, and FoxM1. Each is linked with PLG in more than 2 cancer types. Because this analysis shows association rather than direction, both PLG-to-partner and partner-to-PLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by PLG-low versus PLG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLG→partner) and Y-score (partner→PLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.484	+1.999	.003	.008	3	3
COAD	GAPDH →	+0.549	+1.882	.009	.031	3	3
LUAD	FoxM1 →	+0.286	+3.033	.004	.017	3	2
UCEC	Cyclin-B1 →	+0.670	+4.169	<.001	<.001	2	3
LUAD	Cyclin-E1 →	+0.215	+2.321	.033	.006	3	2
UCEC	Ku80 →	+0.214	+1.428	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

TFRC by PLG expression — UCEC

Explore this box plot interactively →