PLG

Across TCGA cell cohorts, PLG RNA expression is significantly associated with the go_rna of many other GO terms, with 1,233 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PLG-associated GO terms across cancer lineages are Excitatory postsynaptic potential, Viral process, and Positive regulation of protein localization to nucleus. Each is linked with PLG in more than 4 cancer types. Because this analysis shows association rather than direction, both PLG-to-partner and partner-to-PLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Excitatory postsynaptic potential grouped by PLG-low versus PLG-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLG→partner) and Y-score (partner→PLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Excitatory postsynaptic potential →	-0.063	-0.225	.003	<.001	3	5
KIDNEY	Viral process →	+0.082	+0.790	<.001	<.001	3	5
KIDNEY	Positive regulation of protein localization to nucleus →	+0.074	+0.649	<.001	.007	3	5
KIDNEY	Epinephrine transport →	+1.180	+0.776	<.001	.001	3	5
KIDNEY	Negative regulation of cell adhesion →	+0.056	+0.536	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of protein catabolic process in the vacuole →	+0.091	+0.187	.005	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,233 associations by consensus.

Excitatory postsynaptic potential by PLG expression — LUNG_NSCLC_LUAD

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