PLG

Across TCGA cell cohorts, PLG mutation is significantly associated with the RNA expression of many other genes, with 136 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLG-associated genes across cancer lineages are OR52J3, ACSM2A, and OR2T8. Each is linked with PLG in more than 1 cancer types. Because this analysis shows association rather than direction, both PLG-to-partner and partner-to-PLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52J3 grouped by PLG-low versus PLG-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLG→partner) and Y-score (partner→PLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR52J3 →	+0.026	+5.369	<.001	.004	3	2
LUNG_SCLC	ACSM2A →	+0.018	+3.523	.001	.008	3	2
LARGE_INTESTINE	OR2T8 →	+0.137	+2.520	<.001	.001	3	2
LARGE_INTESTINE	F11 →	+0.044	+3.368	<.001	<.001	3	2
BLOOD_Leukemia	BTNL8 →	+0.355	+3.769	<.001	.002	3	2
BLOOD_Leukemia	MAJIN →	+0.198	+3.036	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 136 associations by consensus.

OR52J3 by PLG expression — SOFT_TISSUE

Explore this box plot interactively →