PLEKHS1

Across TCGA patient cohorts, PLEKHS1 protein abundance is significantly associated with the RNA expression of many other genes, with 7,845 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PLEKHS1-associated genes across cancer lineages are CP, BPIFB1, and TOX3. Each is linked with PLEKHS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PLEKHS1-to-partner and partner-to-PLEKHS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHS1 versus CP in HNSC, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHS1→partner) and Y-score (partner→PLEKHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CP →	+2.334	+1.200	.007	.004	3	5
HNSC	BPIFB1 →	+4.431	+0.903	.001	.002	3	4
UCEC	TOX3 →	+1.202	+0.859	<.001	<.001	3	4
PDAC	SERPINI2 →	+2.344	+0.429	<.001	<.001	3	4
BRCA	EHF →	+1.091	+0.547	<.001	<.001	3	4
LUAD	GRAMD2B →	+0.653	+0.813	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,845 associations by consensus.

PLEKHS1 vs CP — HNSC

Explore this scatter interactively →