PLEKHS1

Across TCGA patient cohorts, PLEKHS1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHS1-associated genes across cancer lineages are Caspase-8, A-Raf_pS299, and Fibronectin. Each is linked with PLEKHS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHS1-to-partner and partner-to-PLEKHS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by PLEKHS1-low versus PLEKHS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHS1→partner) and Y-score (partner→PLEKHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.253	-3.432	.017	.005	3	2
SKCM	A-Raf_pS299 →	+0.162	+3.012	.011	.018	3	1
SKCM	Fibronectin →	-0.558	-2.000	.005	.031	3	1
SKCM	HER2_pY1248 →	-0.130	-2.700	.046	.006	2	2
SKCM	p90 RSK →	+0.271	+3.000	.004	.034	3	1
SKCM	Bad_pS112 →	+0.201	+2.700	.015	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Caspase-8 by PLEKHS1 expression — UCEC

Explore this box plot interactively →