PLEKHS1

Across TCGA cell cohorts, PLEKHS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,007 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PLEKHS1-associated GO terms across cancer lineages are Regulation of synapse structural plasticity, Interleukin-10-mediated signaling pathway, and Vesicle budding from membrane. Each is linked with PLEKHS1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PLEKHS1-to-partner and partner-to-PLEKHS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of synapse structural plasticity grouped by PLEKHS1-low versus PLEKHS1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHS1→partner) and Y-score (partner→PLEKHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of synapse structural plasticity →	-1.056	-1.307	<.001	<.001	3	8
CNS	Interleukin-10-mediated signaling pathway →	+0.197	+0.887	<.001	.003	2	8
SOFT_TISSUE	Vesicle budding from membrane →	+0.053	+0.834	.001	.001	3	7
LUNG_NSCLC_LUAD	T cell mediated cytotoxicity →	+0.204	+1.022	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	SRP-dependent cotranslational protein targeting to membrane, translocation →	+0.087	+1.068	.004	.008	3	7
BLOOD_Lymphoma	Macrophage colony-stimulating factor signaling pathway →	+0.730	+0.065	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,007 associations by consensus.

Regulation of synapse structural plasticity by PLEKHS1 expression — SOFT_TISSUE

Explore this box plot interactively →