PLEKHS1

Across TCGA cell cohorts, PLEKHS1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PLEKHS1-associated genes across cancer lineages are OR5B21, OR12D3, and OR4M1. Each is linked with PLEKHS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHS1-to-partner and partner-to-PLEKHS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5B21 grouped by PLEKHS1-low versus PLEKHS1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHS1→partner) and Y-score (partner→PLEKHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR5B21 →	+0.025	+4.672	<.001	.002	3	2
LUNG_NSCLC_LUAD	OR12D3 →	+0.029	+4.228	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR4M1 →	+0.006	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	ZNF729 →	+0.349	+3.481	<.001	.004	3	1
LUNG_NSCLC_LUAD	IQCF5 →	+0.040	+3.604	<.001	.004	3	1
LUNG_NSCLC_LUAD	CT45A9 →	+0.943	+3.959	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

OR5B21 by PLEKHS1 expression — BREAST

Explore this box plot interactively →