PLEKHO2

Across TCGA patient cohorts, PLEKHO2 RNA expression is significantly associated with the protein abundance of many other proteins, with 22,908 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PLEKHO2-associated proteins across cancer lineages are DEF6, AIF1, and FNBP1. Each is linked with PLEKHO2 in more than 9 cancer types. Because this analysis shows association rather than direction, both PLEKHO2-to-partner and partner-to-PLEKHO2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHO2 versus DEF6 in GBM, with a Pearson correlation of 0.77.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHO2→partner) and Y-score (partner→PLEKHO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DEF6 →	+0.645	+0.748	<.001	<.001	3	10
GBM	AIF1 →	+0.770	+0.705	<.001	<.001	3	10
UCEC	FNBP1 →	+0.480	+0.875	<.001	<.001	3	10
UCEC	PLEKHO2_T311 →	+0.658	+0.886	<.001	<.001	3	10
OV	ARHGAP30 →	+0.741	+0.772	<.001	<.001	3	9
GBM	PARVG →	+0.685	+0.780	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,908 associations by consensus.

PLEKHO2 vs DEF6 — GBM

Explore this scatter interactively →