PLEKHO2

Across TCGA patient cohorts, PLEKHO2 protein abundance is significantly associated with the RNA expression of many other genes, with 20,929 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PLEKHO2-associated genes across cancer lineages are CYTH4, NCF4, and CSF2RB. Each is linked with PLEKHO2 in more than 9 cancer types. Because this analysis shows association rather than direction, both PLEKHO2-to-partner and partner-to-PLEKHO2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHO2 versus CYTH4 in GBM, with a Pearson correlation of 0.80.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHO2→partner) and Y-score (partner→PLEKHO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CYTH4 →	+1.174	+0.453	<.001	<.001	3	10
UCEC	NCF4 →	+1.266	+0.505	<.001	<.001	3	10
BRCA	CSF2RB →	+1.377	+0.533	<.001	<.001	3	10
HNSC	SIRPB1 →	+0.671	+0.318	<.001	<.001	3	10
OV	HCK →	+1.289	+0.451	<.001	<.001	3	10
GBM	TLR8 →	+1.148	+0.444	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,929 associations by consensus.

PLEKHO2 vs CYTH4 — GBM

Explore this scatter interactively →