PLEKHO2

Across TCGA patient cohorts, PLEKHO2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHO2-associated genes across cancer lineages are VHL, IRS1, and JNK2. Each is linked with PLEKHO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHO2-to-partner and partner-to-PLEKHO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by PLEKHO2-low versus PLEKHO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHO2→partner) and Y-score (partner→PLEKHO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.877	-3.459	.004	.005	3	2
UCEC	IRS1 →	+0.238	+2.700	.010	.006	3	1
UCEC	JNK2 →	+0.198	+2.834	.026	.034	3	1
UCEC	MEK1 →	+0.326	+2.000	.048	.032	3	1
UCEC	Notch1 →	+0.202	+3.335	.001	.005	3	1
UCEC	p62 Lck ligand →	+0.445	+2.700	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

VHL by PLEKHO2 expression — UCEC

Explore this box plot interactively →